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Maharishi Dayanand, Amity University scientists find breakthrough on reusable biosensor to detect dengue at early stage


Scientists from the Amity University in Noida, and Maharshi Dayanand University in Haryana have synthesized a reusable biosensor that can rapidly detect dengue viruses

By Team ABLE

According to an information filed on PTI, scientists at Amity University have developed a new eco-friendly, reusable biosensor that can rapidly detect dengue viruses from blood samples, an advance that may lead to low cost paper-based tests to diagnose the disease at an early stage.

To make an efficient and versatile sensor, scientists from the Amity University in Noida, and Maharshi Dayanand University in Haryana synthesized the biosensor by depositing nanoparticles of zinc oxide, palladium, and platinum on a fluorine-doped tin oxide electrode. They then coated the electrode with a probe DNA of dengue virus and tested its efficiency in detecting dengue viruses.

The scientists have deposited single stranded DNA (ssDNA) of dengue virus on the electrode. If the patient is suffering from dengue, then its complementary strand will be able to bind the ssDNA on to the surface of electrode. The electrode is connected to a device that can measure current value. These measurements can tell whether the patient has dengue or not. The biosensor can be regenerated by dipping it in a sodium hydroxide solution for five minutes. After regeneration, the scientists claim that it retained its ability to show similar current response when exposed to a target DNA.

This device can be used as a lab-on-chip disease diagnosis platform at a point of care for detecting all individual serotypes of dengue virus on a paper-based substrate, researchers said.

The research was published in the journal Biosensors and Bioelectronics.
Source: PTI