ALICE (Analysis of Infectious Chronic Endometritis) \ndetects the nine pathogens responsible for chronic endometritis, \nincluding Enterobacteriaceae, Enterococcus, Streptococcus, \nStaphylococcus, Mycoplasma and Ureaplasma.
By Team ABLE
Molecular\n diagnostics company Igenomix has developed in what is said to be the \nfirst molecular diagnostic tool for chronic endometritis, to improve the\n reproductive prognosis of infertile women.
Chronic \nendometritis is a condition affecting up to 40% of infertile women, with\n a prevalence as high as 57% in those suffering from recurrent \nmiscarriage and 66% in those with recurrent implantation failure. Recent\n research confirms the importance of the microbial flora of the \nendometrium for reproduction.
Igenomix has revealed in its press\n release that the accuracy of this single molecular test is comparable \nto the combination of traditional hysteroscopy, histology and \nmicrobiology, enabling a more accessible, rapid and cost-effective \ndiagnosis.
Chronic endometritis is a persistent \ninflammation of the endometrial tissue caused by bacterial pathogens. \nAlthough often asymptomatic, it is present in up to 40% of infertile \nwomen and in as many as 66% of women with repeated implantation failure,\n and 57% with unexplained recurrent miscarriage.
ALICE \n(Analysis of Infectious Chronic Endometritis) detects the nine pathogens\n responsible for chronic endometritis, including Enterobacteriaceae, \nEnterococcus, Streptococcus, Staphylococcus, Mycoplasma and Ureaplasma.
\"Until\n now, the diagnosis of this condition was generally carried out through \nhistology (microscopic analysis of the endometrial biopsy), which could \nbe combined with microbial culture. However, not all the micro-organisms\n involved can be cultured. Specifically, between 20% and 60% cannot be \ngrown in standard laboratory conditions and, as a result, information is\n lost. A third option was to undertake a hysteroscopy of the uterine \ncavity, but this method required surgery and didn\'t allow the specific \npathogens in question to be identified,\" said Dr Inmaculada Moreno, \nresearcher at Igenomix and first author of the study -
The\n diagnosis of chronic endometritis in infertile asymptomatic women: a \ncomparative study of histology, microbial cultures, hysteroscopy, and \nmolecular microbiology, published in the American Journal of Obstetrics \n& Gynaecology. The study describes the first molecular diagnostic \ntool for chronic endometritis, which is equivalent in terms of \nsensitivity and accuracy to the three classical diagnostic methods \ncombined.
\"Our aim was to develop a molecular \ndiagnostic tool, comparable, in terms of sensitivity and accuracy, to \nusing the three classical methods combined, overcoming any of their \nindividual or collective shortcomings,\\\" she added.