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Igenomix develops molecular diagnostic tool for chronic endometritis


ALICE (Analysis of Infectious Chronic Endometritis) detects the nine pathogens responsible for chronic endometritis, including Enterobacteriaceae, Enterococcus, Streptococcus, Staphylococcus, Mycoplasma and Ureaplasma.


By Team ABLE

Molecular diagnostics company Igenomix has developed in what is said to be the first molecular diagnostic tool for chronic endometritis, to improve the reproductive prognosis of infertile women.

Chronic endometritis is a condition affecting up to 40% of infertile women, with a prevalence as high as 57% in those suffering from recurrent miscarriage and 66% in those with recurrent implantation failure. Recent research confirms the importance of the microbial flora of the endometrium for reproduction.
Igenomix has revealed in its press release that the accuracy of this single molecular test is comparable to the combination of traditional hysteroscopy, histology and microbiology, enabling a more accessible, rapid and cost-effective diagnosis.

Chronic endometritis is a persistent inflammation of the endometrial tissue caused by bacterial pathogens. Although often asymptomatic, it is present in up to 40% of infertile women and in as many as 66% of women with repeated implantation failure, and 57% with unexplained recurrent miscarriage.
ALICE (Analysis of Infectious Chronic Endometritis) detects the nine pathogens responsible for chronic endometritis, including Enterobacteriaceae, Enterococcus, Streptococcus, Staphylococcus, Mycoplasma and Ureaplasma.

\"Until now, the diagnosis of this condition was generally carried out through histology (microscopic analysis of the endometrial biopsy), which could be combined with microbial culture. However, not all the micro-organisms involved can be cultured. Specifically, between 20% and 60% cannot be grown in standard laboratory conditions and, as a result, information is lost. A third option was to undertake a hysteroscopy of the uterine cavity, but this method required surgery and didn\'t allow the specific pathogens in question to be identified,\" said Dr Inmaculada Moreno, researcher at Igenomix and first author of the study -

The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology, published in the American Journal of Obstetrics & Gynaecology. The study describes the first molecular diagnostic tool for chronic endometritis, which is equivalent in terms of sensitivity and accuracy to the three classical diagnostic methods combined.

\"Our aim was to develop a molecular diagnostic tool, comparable, in terms of sensitivity and accuracy, to using the three classical methods combined, overcoming any of their individual or collective shortcomings,\" she added.